Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450028
2.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490183
3.
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
J Med Chem
; 67(7): 5758-5782, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511649
4.
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Nat Neurosci
; 26(3): 416-429, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36635496
5.
CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun
; 14(1): 5053, 2023 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598178
6.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J Med Chem
; 65(24): 16290-16312, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36469401
7.
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
J Exp Med
; 219(3)2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35226042
8.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Mol Neurodegener
; 17(1): 41, 2022 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35690868
9.
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Sci Transl Med
; 14(648): eabj2658, 2022 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675433
10.
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Sci Rep
; 11(1): 12900, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145320
11.
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome.
JCI Insight
; 6(19)2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34622797
12.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med
; 13(593)2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980574
13.
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461332
14.
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
Cell Rep
; 30(2): 381-396.e4, 2020 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31940483
15.
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron
; 105(5): 837-854.e9, 2020 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902528
16.
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461331
17.
Author Correction: CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun
; 14(1): 5516, 2023 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37679403
18.
BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.
Sci Rep
; 7: 44249, 2017 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28281673
19.
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.
Elife
; 62017 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28440222
20.
Widespread brain distribution and activity following i.c.v. infusion of anti-ß-secretase (BACE1) in nonhuman primates.
Br J Pharmacol
; 174(22): 4173-4185, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28859225